Protein Modification Reagents
Biotium Clostridium difficile (Toxin A)(253/422), CF740 conjugate, 0.1mg/mL
This MAb reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aeruginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation.Primary antibodies are available
Abcam TNB, Yellow chromogenic standard for DTNB thiol quantification, 250MG
MW 199.19 Da, Purity =95%. TNB, Yellow chromogenic standard for DTNB thiol quantification. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC N3-PEG3-VC-PAB-MMAF | 2757277-32-8 | 100.0% | 1352.62 | C66H105N13O17 | 5 MG
N3-PEG3-VC-PAB-MMAF is an azide-functionalized antibody-drug conjugate (ADC) drug-linker conjugate combining a PEG3 spacer, a valine-citrulline cleavable linker with a p-aminobenzyl self-immolative spacer, and the tubulin inhibitor monomethyl auristatin F (MMAF). It is provided as a high-purity click-chemistry reagent for bioconjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition.
- Azide functional group enables CuAAC and SPAAC bioconjugation.
- Includes valine-citrulline-PAB cleavable linker for intracellular payload release.
- Contains monomethyl auristatin F as the cytotoxic payload.
- High purity suitable for research applications (>99.9%).
- Molecular weight 1352.62; formula C66H105N13O17.
- Recommended storage at -20°C under inert atmosphere; in solvent: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC 2-amino-n-(14-azido-2,5-dioxo-9,12-dioxa-3,6-diazatetradecyl)acetamide | 2222277-20-3 | 95.0% | 345.35 g/mol | C12H23N7O5 | 1 ML
Gly-Gly-Gly-PEG2-azide is an azide-functionalized peptide-PEG linker supplied as a ready-to-use solution (10 mM in DMSO, 1 mL) or as a solid. It is intended for use in antibody-drug conjugate synthesis, bioconjugation, and related chemical biology applications.
- Azide-functionalized peptide-PEG2 linker for bioconjugation.
- Available as 10 mM solution in DMSO (1 mL) or solid forms.
- Used for antibody-drug conjugate synthesis and related chemistry.
- Characterized by CAS 2222277-20-3 and molecular weight 345.35 g/mol.
Medchemexpress LLC Ald-Ph-amido-PEG4-C2-NHS ester | 1353011-74-1 | MFCD20926371 | 98.1% | 494.49 | C23H30N2O10 | 1 G
Ald-Ph-amido-PEG4-C2-NHS ester is a noncleavable 4-unit polyethylene glycol (PEG4) NHS ester linker used for antibody-agent conjugation research. It provides an activated N-hydroxysuccinimide (NHS) ester for amine coupling and an aldehyde-phenyl (Ald-Ph) moiety with a two-carbon spacer, suitable for bioconjugation and linker synthesis. Supplied at high reported purity and available in multiple pack sizes.
- Noncleavable 4-unit PEG linker for antibody-agent conjugation.
- Activated NHS ester for efficient amine coupling.
- Aldehyde-phenyl functional group with a C2 spacer.
- Molecular weight 494.49 g/mol.
- Purity approximately 98.1% as reported.
- Available in multiple pack sizes, including 1 G.
Medchemexpress LLC Azide-PEG5-Tos | 236754-49-7 | MFCD28505520 | >98.0% | 417.48 | C17H27N3O7S | 25 G
Azide-PEG5-Tos is an azide-functional polyethylene glycol (PEG) linker consisting of five ethylene glycol units and a tosylate leaving group. It is designed for bioconjugation applications such as antibody-drug conjugate (ADC) synthesis and click chemistry, and is supplied for research use only.
- Cleavable 5-unit PEG linker suitable for ADC and PROTAC synthesis.
- Azide functional group enables copper-catalyzed and strain-promoted azide-alkyne cycloaddition.
- High solubility in DMSO (≥100 mg/mL) and compatible with common in vivo vehicles at ≥2.5 mg/mL.
- Tosylate leaving group allows for further nucleophilic substitution reactions.
- Recommended storage: pure solid at -20°C (long term) or 4°C (short term).
![Medchemexpress LLC 4-((21S,24S)-1-(bicyclo[6.1.0]non-4-yn-9-yl)-21-isopropyl-3,19,22-trioxo-24-(3-ureidopropyl)) | 2762519-08-2 | MFCD32062688 | 98.8% | 1546.93 g·mol⁻¹ | C80H127N11O19 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203931.png-250.jpg)
Medchemexpress LLC 4-((21S,24S)-1-(bicyclo[6.1.0]non-4-yn-9-yl)-21-isopropyl-3,19,22-trioxo-24-(3-ureidopropyl)) | 2762519-08-2 | MFCD32062688 | 98.8% | 1546.93 g·mol⁻¹ | C80H127N11O19 | 1 MG
endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable antibody-drug conjugate (ADC) linker containing an endo-bicyclononyne (BCN) click handle and a PEG4 spacer conjugated to monomethyl auristatin E (MMAE). It is used for ADC synthesis and for bioconjugation via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Cleavable Val-Cit-PAB linker for enzymatic release of payload.
- Contains a PEG4 spacer to improve solubility and linker flexibility.
- Endo-BCN group enables copper-free click conjugation to azide-bearing molecules.
- Conjugated to MMAE for use in antibody-drug conjugate research.
- Supplied in small milligram quantities for research and synthesis workflows.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 | C19H22N2O8 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203957.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 | C19H22N2O8 | 250 MG
Ald-Ph-amido-PEG2-C2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker designed for antibody-drug conjugation (ADC). It features an activated N-hydroxysuccinimide (NHS) ester for amine coupling and a para-formylbenzoyl aldehyde for conjugation chemistry. The product is supplied as a colorless to light-yellow liquid with high purity and is intended for research use.
- Noncleavable two-unit PEG linker suitable for ADC construction.
- NHS ester for efficient amine coupling.
- Aldehyde (formyl) functional group for site-specific conjugation.
- High purity (approximately 98.5%).
- Liquid, colorless to light yellow appearance.
- Molecular weight 406.39 and formula C19H22N2O8.
- Storage: pure form -20°C; in solvent -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Carboxyethyl-γ-aminobutyric acid | 4386-03-2 | 98.0% | 175.18 g/mol | C7H13NO4 | 5 MG
Carboxyethyl-γ-aminobutyric acid is a small-molecule derivative of γ-aminobutyric acid used as a biochemical assay reagent for research applications. The compound is supplied as a solid (CAS 4386-03-2) with molecular weight 175.18 g/mol and chemical formula C7H13NO4.
- High purity: 98.0% as supplied
- Small-molecule GABA derivative suitable for biochemical assays
- Available in low-mass packs for small-scale experiments
- Supplied as a solid for ease of handling and storage
- SDS and batch documentation available for safety and quality traceability
Medchemexpress LLC (S)-Benzyl 27-benzyl-1-(9H-fluoren-9-yl) hexaoxahexaazahexatriacontan-oate | 2914227-56-6 | 99.7% | 983.07 | C51H62N6O14 | 5 MG
Fmoc-PEG4-GGFG-CH2-O-CH2-Cbz is an Fmoc-protected, PEG4-containing cleavable linker used for the synthesis of antibody-drug conjugates (ADCs). It is supplied as a high-purity solid reagent for research-scale bioconjugation and linker-payload assembly.
- Fmoc-protected functionality for standard peptide coupling workflows.
- Four-unit PEG spacer to improve solubility and provide distance between antibody and payload.
- Cleavable linker chemistry suitable for assembly and payload release strategies.
- High purity (>99.6%) solid, suitable for research and development applications.
- Recommended storage: 4°C sealed; in solvent store at -80°C for long-term storage.
Medchemexpress LLC N6-(1-carboxyethyl)-L-lysine | 5746-03-2 | MFCD30364298 | 99.9% | 218.25 | C9H18N2O4 | 10 MG
Nε-(Carboxyethyl)lysine (CEL) is an advanced glycation end product used in biochemical and cellular research to study protein glycation, receptor for AGE (RAGE) signalling, and related pathological processes. It is supplied as a white to off-white solid with high analytical purity for laboratory applications.
- High purity (99.9%) suitable for analytical and cellular studies.
- Used to model advanced glycation end product formation and protein cross-linking.
- Interacts with RAGE receptor pathways to study inflammatory signaling.
- Modulates glutamate transporters and affects neurotransmission-related assays.
- Characterized chemical identity with CAS 5746-03-2 and defined molecular weight.
- Provided as a solid for ease of handling and storage.
- For research use only; not for human or clinical use.